Huntington's disease, or Huntington's chorea, is a progressive neurodegenerative disease of the central nervous system that is inherited genetically through an autosomal dominant trait. (Webster) It is caused by a mutation on the Huntingtin protein in which the CAG repeat region is elongated. CAG is responsible for coding glutamine. This mutation causes many devastating effects and is ultimately fatal. There is no known cure. The disease causes many symptoms, including chorea, which is characterized by irregular, involuntary movements of the body. The disease causes neurodegeneration in the brain, including the caudate, putamen, and cortex. This will cause cognitive decline as the disease progresses further. Furthermore, weight loss is a common feature of Huntington's disease, and it is very difficult for HD patients to maintain an adequate body weight. Problems with mitochondrial dysfunction and energy metabolism are also seen, including lack of ATP production in the muscles, reduced electron transport chain activity, and impaired energy metabolism in both the brain and brain.. ...