Many elderly patients take NSAIDs chronically. There are many adverse effects associated with chronic NSAID use, including the risk of acute renal failure, stroke/myocardial infarction, peptic ulcer, as well as worsening of other chronic diseases including heart failure and hypertension. NSAIDs can also interact with some drugs (warfarin, corticosteroids), consequently increasing hospital admissions among the elderly population. Adverse drug events are more likely to affect geriatric patients due to the physiological changes that occur with aging, from changes in renal function to metabolic changes. Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get Original Essay Nonsteroidal anti-inflammatory drugs are a common class of analgesics generally used chronically for pain such as musculoskeletal pain including osteoarthritis. It is commonly used in the elderly population. About 40% of people over the age of 65 receive one or more NSAID prescriptions each year, not including over-the-counter NSAIDs. The main risk factors for ADR hospitalizations are advanced age, polypharmacy, comorbidity and potentially inappropriate medications. A study highlighted the need for an ADR event prediction tool to identify high-risk patients (elderly population) and therefore direct appropriate interventions towards the prevention of ADRs. related hospital admissions. The study further highlighted the role of GPs and community pharmacists in identifying ADR-prone patents. (7). Currently, there are no validated tools to assess the risk of ADRs in primary care. According to a systematic review and meta-analysis performed through a computerized search in major databases, between 1988 and 2015, addressing hospital admissions induced by adverse drug reactions in patients over 60 years of age, NSAIDs were the most common drug-induced adverse event. effects that led to hospital admissions ranging between 2.3 and 33.3%. According to a prospective cohort study conducted, participating pharmacies were called the intervention group (IG) and received feedback on drug distribution in non-selective NSAID users aged 60 years and older at risk of UGI harm and were in charge of selecting patients to improve the prescription of ns-NSAIDs, in collaboration with general practitioners. Users of NSAIDs from other pharmacies without concomitant use of gastroprotective agents (GPAs) were followed in parallel as a control group (CG). Changes in ns-NSAID users' UGI risk between baseline and follow-up measurements, as assessed by the addition of GPA or cessation of ns-NSAIDs, were compared between the two study arms. The results showed that persistent users of ns-NSAIDs among selected IG patients had an additional 7% chance of reducing the risk of UGI at follow-up (odds ratio 0.93, 95% confidence interval 0.89 -0.97) compared to CG patients. In the IG, 91% of selected IG patients at risk of UGI from ns-NSAIDs at baseline no longer had an increased risk at follow-up due to cessation of ns-NSAIDs or concomitant use of GPA. sample. Get a custom paper from our expert writers now. Get a Custom Essay There is approximately one in 1,000 persons per year in the general population with an incidence of hospitalization for complicated peptic ulcer among non-users of anti-inflammatory drugs compared to four and five hospitalization events among users of a -NSAIDs.