The well-defined group is L. acidophilus which divides into phylogenetic subgroups of Lactobacillus. Its meaning, although it is moderately constructed by DNA-DNA homology, from 32% to 50% of the constituent content existing in genomic species (GC) (Felis & Dellaglio., 2007). Between the ephemeral and permanent residents of the normal intestinal flora, Lactobacillus acts as a reservoir of antibiotic resistance genes and offers a model locus for parallel gene transfer (Devirgiliis et al., 2011). THE. coli has the ability to colonize different anatomical sites partly thanks to the plasticity and transformation of the genome by acquiring or losing genetic material from which it has obtained resistance or virulence influences. Therefore, horizontal transfer remains an important factor in the adaptation and evolution of E. coli towards different niches (Ahmed et al., 2008; Mellata et al., 2010). Say no to plagiarism. Get a tailor-made essay on "Why Violent Video Games Shouldn't Be Banned"? Get an original essay UPEC strains can trigger acute infections and recurrent infections that do not respond to common antimicrobial treatments. ß[n1][n2]-lactam antibiotics, fluoroquinolones or trimethoprim/sulfamethoxazole are generally included in the treatment of urinary tract infections (Chulain et al., 2005; Johnson et al., 2004; Molina-López et al. , 2011). According to Johnson (2000) treatment depends on the patient's age, sex, pathogen involvement, disease course and anatomical areas of the urinary tract. The influence of resistance may be associated with changes in the bacterial genome through acquisition or mutation or horizontal transmission of extra chromosomal or chromosomal material (Moura et al., 2009; Backer et al., 2008; Hong et al., 2009). Antibiotic resistance related to certain mutations occurs randomly. They represent the significance of defects during DNA duplication or disorganization in DNA damage repair mechanisms in bacterial cell division and are recognized as natural mutations. The result of this is few changes in seven positions of the gyrA gene and in three positions of the parC gene. The quinolone-resistant phenotype of Escherichia coli. Antibiotic resistance mechanisms involving efflux or import systems are genetically determined by mutations in gene regulatory regions and even promoter regions known as multidrug resistance (MDR) efflux pumps (Piddock., 2006; Depardieu et al, 2007). Some changes occur in cells that do not divide or in cells that have a low rate of division and are related to nonlethal selective pressure that favors bacterial cells. These mutations are called adaptive and represent the main source of the appearance of antibiotic-resistant phenotypes under natural conditions. The main points of these processes are the error-prone DNA polymerase V (umuCD) and DNA polymerase IV (dinB) that transiently increase the rate of mutations. By increasing the rate of emergence of antibiotic-resistant phenotypes of Escherichia coli, some antibiotics are capable of producing bacterial DNA damage and triggering the mutagenic SOS response. Accumulation of single-stranded DNA due to injury that blocks bacterial chromosome replication leads to the formation of RecA nucleoprotein complexes. A necessary step to assemble the mutagen-dependent DNA polymerase V UmuD'2C is another role of the RecA coprotease is to transform UmuD into UmuD'. It has allowed DNA replication to remain this way, the cost of which is loss of reliability and the entry of mutations (Rosche & Foster., 2000; Sutton et al., 2000, Bjedov et.