“Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury, leading to portal hypertension and disease End-stage liver disease (ESLD) that progresses to cirrhosis and ultimately leads to decompensated liver disease. “Say no to plagiarism. Get a tailor-made essay on “Why violent video games should not be banned”? Get an original essay Cirrhosis is one of the leading causes of death in Asia as it ranks tenth among the most common causes of death in the United States, while globally it is the leading cause Twelfth most common cause. Medical treatments that may slow the progression of compensated cirrhosis to decompensated cirrhosis are being researched, however, it is the only option in a select subgroup of patients with ESLD and HCC. Vitamin D is also known to have multiple extraskeletal functions. The liver is the main organ involved in the synthesis and metabolism of vitamin D, after the kidneys active form There are various experimental studies that have demonstrated an increased prevalence of vitamin D deficiency and insufficiency in patients with chronic liver disease and cirrhosis. It is often observed that sometimes, even in the absence of cirrhosis, a vitamin D deficiency can be found in the majority of subjects. However, subjects who had cirrhosis, vitamin D deficiency (there are various studies that state that vitamin D deficiency D is related to the pathophysiology of cirrhosis. There are studies that have shown (to some extent) that vitamin D levels are inversely correlated with levels of liver dysfunction as evidenced by the Child Pugh score and the MELD score. Additionally, vitamin D deficiency D has been implicated in the increased risk of overall mortality and infections in patients with cirrhosis. Recently, a study revealed an increase in MELD score observed in transplant cases to be associated with vitamin D deficiency. liver for fat-soluble vitamins, vitamin B12, is one of them. The liver stores about 1 mg. In patients with chronic liver disease or cirrhosis, high levels of vitamin B12 in the serum are often found. normal have also been found in some patients, particularly in patients with long-standing portal cirrhosis. Please note: this is just a sample. Get a custom paper from our expert writers now. Customize Essay Some studies have indicated that high serum levels of vitamin B12 could be a sign of a serious, life-threatening disease. Very high vitamin B12 levels have been observed in patients with advanced stages of viral liver cirrhosis. There is only one report that demonstrated the association of vitamin B12 levels with disease severity and mortality in short-term hepatitis B virus infection. No reports have evaluated the dynamics of vitamin B12 in chronic viral hepatitis. Therefore, the present study aimed to evaluate the relationship between serum vitamin B12 and disease severity and long-term prognosis of liver disease in patients with cirrhosis...