Over 17 million Americans suffer from an alcohol use disorder, the majority of which is alcoholism. (NIH, 2014) It is reported that over 15% of these 17 million people never seek treatment for their disorder. Those faced with the task of conquering alcohol use disorder are faced with many options when it comes to treatment. One of the most medically controversial drugs is Disulfiram (Antabuse). This drug reacts negatively with alcohol and will send the person's body into a state of turmoil to hopefully combat the serious alcohol problem. Like any drug, Antabuse has its few problems here and there, but overall, this treatment appears to be an extremely effective way to free those suffering from alcohol use disorders. As the first drug to be approved by the FDA to combat alcoholism, Antabuse took sufferers by storm and sent their bodies into a state of shock. Antabuse reacts with alcohol and affects the central nervous system (CNS) as it is unable to metabolize acetaldehyde. (SAMHSA, 2009) Antabuse can also be considered an anti-craving drug because it increases dopamine and decreases norepinephrine in the body, reducing the desire to drink alcohol. (Vaccari et. al. 1996) The Antabuse/Alcohol reaction occurs 10-30 minutes after alcohol consumption. (SAMHSA, 2009) Depending on the amount of alcohol consumed, the severity of the reaction will vary. A BAC of 5-10 mg will cause a mild reaction, while a BAC of 125 mg or more the reaction may leave the patient unconscious. The Antabuse/Alcohol reaction can cause different types of symptoms including; sweating, hyperventilation, blurred vision, nausea/vomiting, heart palpitations, confusion and whole body… half of the paper… and confirms them. Antabuse treatment is only effective when used correctly and continuously, so if the patient is incapable of one of these, he may be better suited for another type of treatment for alcoholism. Some may argue that the reactions caused by Antabuse are too harsh for any patient to endure. when they try to overcome their alcoholism disorder. Other studies show that Antabuse alone, or better yet, with another type of therapy, has the highest rate of abstinence days. For some people it may take the shock of stomach pains or lightheadedness to show them the reality of the illness they have. The prescribing guidelines for Antabuse are strict, to prevent it from getting into the wrong hands of someone who may not be able to handle its effects. All in all, Antabuse is a great tool to help people in need fight alcoholism disorder until they complete abstinence.
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