Lysosomes are specialized vesicles found inside eukaryotic cells; they contain digestive enzymes that break down any unknown material that enters the cell. The actual name “lysosome” means liberating body, the enzymes it produces cause lysis otherwise known as disintegration. These enzymes are mainly used to break down bacteria absorbed by the cell or to break down any worn out parts of the cell. The enzymes present in the lysosome are so powerful that, if they were released, they could destroy the host cell; therefore in most normal cells they remain in quarantine in the lysosome membrane. The main functions of lysosomes are to break down any single protein, into all types of biological polymers including proteins, nucleic acids, carbohydrates and lipids. In other words, lysosomes can be seen as the digestive system of cells. There are various ways in which lysosomes clear the cell of intrusions, one of the most common methods is through phagocytosis whereby the lysosome actually eats the bacteria or virus and can recycle its receptor proteins into the cell wall through the 'endocytosis. For the lysosome to function, it needs a pH level of 4.5. With such an acidic pH, it can cause a lot of damage to the intracellular fluid, which itself is alkaline with a high pH level. Fortunately, lysosomes have a surrounding membrane that protects any damage to the cell cytosol. There are over 50 known diseases associated with lysosome dysfunction, such as Gaucher disease, Tay Sachs disease, Pompe disease, and beta-galactosidase deficiency. Including many in which the lysosome cannot break down material entering the cell and thus retain it rather than disintegrate it, there are others in which the lysosome... the paper medium... is ineffective." (Kelly, Jeffrey Dr.) The Dr. Jeffrey Kelly further adds, “The research is particularly promising because we have improved the cellular folding and function of mutated lysosomal enzymes, whose deficient function is linked to lysosomal storage diseases, using two distinct categories of FDA-approved enzyme drugs that have been shown to be safe and effective for the treatment of high blood pressure and muscle spasms,” The first author of this research study, Derrick Sek Tong Ong states: “We wanted to discover general principles that could be applied to a variety of misfolding diseases of loss-of-function proteins. This study reveals how we can improve the ability of the cellular machinery to fold and transport a mutant enzyme, so that the protein can function better," This study helped us come to the conclusion that prescription drugs help restore normal cellular function.
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